> Thymosin Alpha-1 10 mg · Lumera Labs
For laboratory research use only. Not for human consumption. Free cold-chain shipping over $130 CAD · Ships from Kelowna, BC
Free cold-chain shipping over $200 CAD · Ships from Kelowna, BC
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Thymosin Alpha-1 10 mg vial
4.7 · 156 researcher reviews
Immune · Repair

Thymosin Alpha-1

SKU LUM-TA1-5 · C₁₂₉H₂₁₅N₃₃O₅₅ · 3108.31 g/mol · CAS 62304-98-7

A 28-residue acetylated peptide originally isolated from thymic extracts. Studied as a modulator of cell-mediated immunity and dendritic-cell function.

Purity (HPLC)
≥ 99.18%
Net peptide
5.00 mg ± 2%
Endotoxin
< 0.5 EU/mg
Format
Lyophilized vial
Storage
−20 °C, desiccated
Shelf life
24 months from MFG
$130CAD / 10 mg vial
In stock · Lot 26-A031
Qty
Bulk 10+: $24 / vial
Add $200 for free cold-chain shipping
  • HPLC + MS verified per lot
  • Cold-chain to your door
  • COA bundled with shipment
  • Lot retains kept 5 years

Overview

Thymosin Alpha-1 is a 28-residue N-terminally acetylated peptide originally purified from thymic extracts and now manufactured by solid-phase synthesis. It is investigated for its effects on T-cell maturation, dendritic-cell activation, and Toll-like-receptor signaling.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

T-cell differentiation and CD4/CD8 phenotyping, dendritic-cell activation and IFN-γ secretion assays, TLR2/TLR9 modulation studies, and in-vitro antiviral screening models.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

ParameterValue
SequenceAc-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Molecular formulaC₁₂₉H₂₁₅N₃₃O₅₅
Molecular weight3108.31 g/mol
CAS number62304-98-7
Length28 residues

Quality

TestSpecification
HPLC purity≥ 99.0% (lot LM-2634: 99.20%)
Mass confirmationESI-MS within 0.5 Da
Net peptide content≥ 80% by AAA
Endotoxin< 0.5 EU/mg (LAL)
Bioburden< 10 CFU/g
Residual TFA< 1.0%

Lot LM-2634

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

MethodResult
RP-HPLC at 220 nm99.20% main peak
ESI-MS (positive)3108.3 Da (theor. 3108.31)
Amino acid analysis82.1% net peptide
LAL endotoxin< 0.05 EU/mg
Karl Fischer (water)2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Goldstein AL, Goldstein AL. From lab to bedside: emerging clinical applications of thymosin alpha 1. Expert Opin Biol Ther. 2009;9(5):593–608.

Romani L et al. Thymosin alpha 1 activates dendritic cells. Blood. 2004;103(11):4232–4239.

King R, Tuthill C. Immune modulation with thymosin alpha 1 treatment. Vitam Horm. 2016;102:151–178.

Citing this material

Thymosin Alpha-1 reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-TA1-5, Lot 26-A031.

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Why Lumera

  • Janoshik Analytical HPLC ≥ 99.18% on this lot
  • LC-MS identity confirmed before release
  • LAL endotoxin below detection limit
  • Cold-chain shipped −20°C from Kelowna, BC
Background research

What the literature says about Thymosin Alpha 1.

Mechanism

Thymosin Alpha 1 is an immune-modulating peptide, classified within the innate + adaptive immunity pathway. Structurally it is a 28-residue acetylated peptide. Thymosin Alpha-1 (Tα1) is a 28-residue acetylated peptide first isolated by Goldstein et al. (1977) from bovine thymus. It modulates dendritic-cell maturation and T-cell function.

In an in-vitro setting, Thymosin Alpha 1 interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

  • In-vitro receptor-binding and dose-response screens against the innate + adaptive immunity target panel.
  • Comparative pharmacology against related class members and previously published reference standards.
  • Time-course studies leveraging Thymosin Alpha 1's known stability profile.
  • Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Thymosin Alpha 1 arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

  1. Goldstein AL et al. Proc Natl Acad Sci USA. 1977;74(2):725-9.
  2. Romani L et al. Ann N Y Acad Sci. 2010;1194:191-8.
  3. Costantini C et al. Front Immunol. 2019;10:873.

For laboratory research only. Thymosin Alpha 1 is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.

$130 CAD