Is Semax from Lumera Labs HPLC verified?

Yes. Every Semax lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

Is Semax sold for human use?

No. Semax is sold strictly as a laboratory reference standard for in-vitro research. It is not approved by Health Canada or the FDA for human use. Every order requires a research-use declaration.

How is Semax shipped?

Semax is lyophilized at synthesis, sealed under nitrogen, and shipped from Kelowna, BC at -20 C through cold-chain insulated packaging via Canada Post Xpresspost. Free shipping over $200 CAD. 24-48h transit Canada-wide.

Where can I see the COA for Semax?

Each shipment includes a lot-specific Certificate of Analysis. The current lot's COA is also published at https://lumerapeptide.com/lab-results/ and can be cross-referenced by the batch number printed on each vial.

4.8 · 225 researcher reviews

Cognitive · Nootropic peptide

Semax

SKU LUM-SEMAX-30 · C₃₉H₅₄N₁₀O₁₀S · 854.97 g/mol · CAS 80714-61-0

A heptapeptide analog of ACTH(4-10) with neuroprotective and BDNF-modulating activity. Investigated as a research tool for cognitive pharmacology.

Purity (HPLC): ≥ 99.2%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$80CAD / 10 mg vial

In stock · Lot 26-A031

Qty

Bulk 10+: $24 / vial

Add $200 for free cold-chain shipping

HPLC + MS verified per lot
Cold-chain to your door
COA bundled with shipment
Lot retains kept 5 years

Overview

Semax is a synthetic heptapeptide analog of ACTH(4-7) extended by a Pro-Gly-Pro tripeptide. Unlike full ACTH, it does not stimulate corticosteroid release; instead, it modulates BDNF expression, NGF/TrkA signaling, and dopaminergic/serotonergic activity in the CNS.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

BDNF/NGF expression assays in cortical neurons, behavioral pharmacology in rodent learning/memory paradigms, and TrkA/TrkB signaling investigations.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Molecular formula	C₃₉H₅₄N₁₀O₁₀S
Molecular weight	854.97 g/mol
CAS number	80714-61-0
Length	7 residues

Quality

Test	Specification
HPLC purity	≥ 99.0% (lot LM-2660: 99.22%)
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2660

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.22% main peak
ESI-MS (positive)	855.0 Da (theor. 854.97)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Levitskaya NG et al. Effects of semax and its C-terminal fragment Pro-Gly-Pro on the behavior of white rats. Neurosci Behav Physiol. 2002;32(4):355–360.

Dolotov OV et al. Semax, an analog of ACTH(4-10), and its des-glycine analog: synthesis, biological activity. J Mol Neurosci. 2006;28(2):133–141.

Andreeva LA et al. Synthetic heptapeptide Semax. Russ J Bioorg Chem. 2010;36(4):457–467.

Citing this material

Semax reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-SEMAX-30, Lot 26-A031.

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Why Lumera

Janoshik Analytical HPLC ≥ 99.2% on this lot
LC-MS identity confirmed before release
LAL endotoxin below detection limit
Cold-chain shipped −20°C from Kelowna, BC

Background research

What the literature says about Semax.

Mechanism

Semax is a synthetic ACTH 4-7 analog, classified within the neurotrophic signaling pathway. Structurally it is a Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide. Semax is a synthetic heptapeptide analog of ACTH(4-10) developed by Russian neuroscientists. Levitskaya et al. (2002) reviewed its nootropic and neuroprotective effects in animal models.

In an in-vitro setting, Semax interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

In-vitro receptor-binding and dose-response screens against the neurotrophic signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Semax's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Semax arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

Levitskaya NG et al. Neurosci Behav Physiol. 2002;32(4):355-9.
Dolotov OV et al. Brain Res. 2006;1117(1):54-60.
Kost NV et al. Peptides. 2002;23(11):1953-60.

For laboratory research only. Semax is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.