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A synthetic tripeptide (Glu-Asp-Arg) studied for neuronal survival and oxidative-stress pathways in CNS research models.
Pinealon is a synthetic tripeptide investigated for neuroprotective and antioxidant activity in CNS research. The peptide is studied for effects on neuronal survival, oxidative-stress markers, and circadian-axis gene expression in rodent and cell-culture models.
Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.
Neuronal-survival assays under oxidative stress, in-vitro Aβ-toxicity protection screens, and circadian-clock gene-expression studies.
Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.
| Parameter | Value |
|---|---|
| Sequence | Glu-Asp-Arg |
| Molecular formula | C₁₆H₂₂N₆O₆ |
| Molecular weight | 394.39 g/mol |
| CAS number | 1438851-62-1 |
| Length | 3 residues |
| Test | Specification |
|---|---|
| HPLC purity | ≥ 99.0% (lot LM-2664: 99.16%) |
| Mass confirmation | ESI-MS within 0.5 Da |
| Net peptide content | ≥ 80% by AAA |
| Endotoxin | < 0.5 EU/mg (LAL) |
| Bioburden | < 10 CFU/g |
| Residual TFA | < 1.0% |
Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.
| Method | Result |
|---|---|
| RP-HPLC at 220 nm | 99.16% main peak |
| ESI-MS (positive) | 394.4 Da (theor. 394.39) |
| Amino acid analysis | 82.1% net peptide |
| LAL endotoxin | < 0.05 EU/mg |
| Karl Fischer (water) | 2.8% w/w |
Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.
Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.
Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.
Khavinson VK et al. Tripeptide bioregulators in studies of biological aging. Bull Exp Biol Med. 2011;151(5):556–559.
Khavinson VK, Kuznik BI. Peptides, genome, and aging. Adv Gerontol. 2012;25(3):457–470.
Anisimov VN, Khavinson VK. Peptide bioregulation of aging. Biogerontology. 2010;11(2):139–149.
Pinealon reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-PIN-20, Lot 26-A031.