Is MOTS-c from Lumera Labs HPLC verified?

Yes. Every MOTS-c lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

Is MOTS-c sold for human use?

No. MOTS-c is sold strictly as a laboratory reference standard for in-vitro research. It is not approved by Health Canada or the FDA for human use. Every order requires a research-use declaration.

How is MOTS-c shipped?

MOTS-c is lyophilized at synthesis, sealed under nitrogen, and shipped from Kelowna, BC at -20 C through cold-chain insulated packaging via Canada Post Xpresspost. Free shipping over $200 CAD. 24-48h transit Canada-wide.

Where can I see the COA for MOTS-c?

Each shipment includes a lot-specific Certificate of Analysis. The current lot's COA is also published at https://lumerapeptide.com/lab-results/ and can be cross-referenced by the batch number printed on each vial.

4.9 · 242 researcher reviews

Longevity · Mitochondrial-derived peptide

MOTS-c

SKU LUM-MOTSC-10 · C₁₀₀H₁₅₈N₂₆O₂₂S · 2174.55 g/mol · CAS 1627580-64-6

A 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene. Studied for AMPK activation and metabolic homeostasis.

Purity (HPLC): ≥ 99.16%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$90CAD / 10 mg vial

In stock · Lot 26-A031

Qty

Bulk 10+: $24 / vial

Add $200 for free cold-chain shipping

HPLC + MS verified per lot
Cold-chain to your door
COA bundled with shipment
Lot retains kept 5 years

Overview

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-residue peptide encoded within the mitochondrial genome and translated in the cytoplasm. It activates AMPK, modulates folate–methionine cycling, and is investigated for its roles in glucose homeostasis, exercise capacity, and longevity pathways.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

AMPK-activation screens (Thr172 phosphorylation), 5-methyl-THF/SAM metabolomics, in-vitro glucose-uptake assays in skeletal myoblasts, and comparative mitochondrial-derived peptide pharmacology.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	MRWQEMGYIFYPRKLR
Molecular formula	C₁₀₀H₁₅₈N₂₆O₂₂S
Molecular weight	2174.55 g/mol
CAS number	1627580-64-6
Length	16 residues

Quality

Test	Specification
HPLC purity	≥ 99.0% (lot LM-2632: 99.13%)
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2632

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.13% main peak
ESI-MS (positive)	2174.6 Da (theor. 2174.55)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015;21(3):443–454.

Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.

Kim KH et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression. Cell Metab. 2018;28(3):516–524.

Citing this material

MOTS-c reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-MOTSC-10, Lot 26-A031.

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Why Lumera

Janoshik Analytical HPLC ≥ 99.16% on this lot
LC-MS identity confirmed before release
LAL endotoxin below detection limit
Cold-chain shipped −20°C from Kelowna, BC

Background research

What the literature says about Mots C.

Mechanism

Mots C is a mitochondrial-derived peptide, classified within the mitochondrial-nuclear signaling pathway. Structurally it is a 16-residue MDP from MT-RNR1. MOTS-c is a 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene. Lee et al. (2015) demonstrated its role in metabolic homeostasis through AMPK activation.

In an in-vitro setting, Mots C interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

In-vitro receptor-binding and dose-response screens against the mitochondrial-nuclear signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Mots C's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Mots C arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

Lee C et al. Cell Metab. 2015;21(3):443-54.
Reynolds JC et al. Nat Commun. 2021;12:470.
Yen K et al. Trends Endocrinol Metab. 2013;24(5):222-8.

For laboratory research only. Mots C is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.