Is GHK-Cu from Lumera Labs HPLC verified?

Yes. Every GHK-Cu lot Lumera Labs ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

Is GHK-Cu sold for human use?

No. GHK-Cu is sold strictly as a laboratory reference standard for in-vitro research. It is not approved by Health Canada or the FDA for human use. Every order requires a research-use declaration.

How is GHK-Cu shipped?

GHK-Cu is lyophilized at synthesis, sealed under nitrogen, and shipped from Kelowna, BC at -20 C through cold-chain insulated packaging via Canada Post Xpresspost. Free shipping over $200 CAD. 24-48h transit Canada-wide.

Where can I see the COA for GHK-Cu?

Each shipment includes a lot-specific Certificate of Analysis. The current lot's COA is also published at https://lumerapeptide.com/lab-results/ and can be cross-referenced by the batch number printed on each vial.

4.6 · 329 researcher reviews

Cosmetic · Repair

GHK-Cu

SKU LUM-GHKCU-50 · C₁₄H₂₄CuN₆O₄ · 403.94 g/mol · CAS 49557-75-7

A naturally-occurring copper-binding tripeptide (Gly-His-Lys) supplied as a 1:1 Cu²⁺ complex. Studied for collagen synthesis, antioxidant activity, and skin-repair pathways.

Purity (HPLC): ≥ 99.42%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$50CAD / 50 mg vial

In stock · Lot 26-A031

Qty

Bulk 10+: $24 / vial

Add $200 for free cold-chain shipping

HPLC + MS verified per lot
Cold-chain to your door
COA bundled with shipment
Lot retains kept 5 years

Overview

GHK-Cu is the copper(II) complex of the tripeptide Gly-His-Lys, originally identified in human plasma. It is investigated for upregulation of collagen and glycosaminoglycan synthesis, antioxidant activity, and modulation of fibroblast and stem-cell behavior in dermal-repair models.

Each vial is lyophilized from a buffered solution, sealed under nitrogen, and shipped cold-chain at −20 °C from our Kelowna facility.

Research applications

Fibroblast collagen and elastin synthesis assays, antioxidant capacity screens, in-vitro wound-closure (scratch) assays, hair-follicle dermal-papilla cell models, and copper-chelation comparative studies.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	Gly-His-Lys (with Cu²⁺ bound to histidine imidazole + amide nitrogens)
Molecular formula	C₁₄H₂₄CuN₆O₄
Molecular weight	403.94 g/mol
CAS number	49557-75-7
Length	Tripeptide-copper complex

Quality

Test	Specification
HPLC purity	≥ 99.0% (lot LM-2640: 99.18%)
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2640

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Lumera QC, Kelowna BC. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.18% main peak
ESI-MS (positive)	403.9 Da (theor. 403.94)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide. Int J Mol Sci. 2018;19(7):1987.

Maquart FX et al. Stimulation of collagen synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. FEBS Lett. 1988;238(2):343–346.

Pickart L et al. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging. Biomed Res Int. 2012;2012:324832.

Citing this material

GHK-Cu reference standard, ≥99% (HPLC), Lumera Labs Inc., Cat. No. LUM-GHKCU-50, Lot 26-A031.

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Why Lumera

Janoshik Analytical HPLC ≥ 99.42% on this lot
LC-MS identity confirmed before release
LAL endotoxin below detection limit
Cold-chain shipped −20°C from Kelowna, BC

Background research

What the literature says about Ghk Cu.

Mechanism

Ghk Cu is a copper-binding tripeptide, classified within the wound-repair signaling pathway. Structurally it is a Gly-His-Lys + Cu²⁺ chelation complex. GHK-Cu is a copper-bound tripeptide naturally present in plasma at higher concentrations in young adults than in older ones. Pickart and Margolina (2018) characterized its broad signal-modulating effects on fibroblast proliferation, collagen synthesis, and antioxidant gene expression.

In an in-vitro setting, Ghk Cu interacts with its target receptor(s) at low-nanomolar affinities under standard binding-assay conditions. Reconstitution should be performed in sterile bacteriostatic water at the working concentration your protocol specifies; the lyophilized vial is sealed under nitrogen and stable at −20 °C until reconstituted.

Common research applications

In-vitro receptor-binding and dose-response screens against the wound-repair signaling target panel.
Comparative pharmacology against related class members and previously published reference standards.
Time-course studies leveraging Ghk Cu's known stability profile.
Cross-batch HPLC fingerprint comparison against the lot-specific COA we publish for every release.

Storage & handling

Ghk Cu arrives lyophilized at −20 °C in cold-chain insulated packaging. On receipt, transfer immediately to a −20 °C freezer. Once reconstituted, store at 2-8 °C and use within the window noted on the lot's COA. Avoid repeated freeze-thaw cycles.

References

Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):1987.
Maquart FX et al. Connect Tissue Res. 1996;34(3):175-82.
Pickart L et al. BioMed Res Int. 2015;2015:648108.

For laboratory research only. Ghk Cu is sold strictly as an in-vitro reference standard. It is not approved for human or veterinary use by Health Canada or the FDA.